Contact Information

Aquatic Biotechnology and Environmental Lab (ABEL)

Research Areas

The main focus of my research is on using fish as models to meet the dual needs for improved assessment of genetic damage associated with exposure to chemical and physical mutagens in the environment, and for new animal models for investigations into basic mechanisms of mutagenesis.

Honors

In 2003 Dr. Winn was a recipient of the Creative Research Medal. This award  recognizes his exceptional accomplishments in creativity and research.  To read more about this award click on the link to creative research medal site. http://www.ovpr.uga.edu/creativeresearch/awardwinners/WinnRichardN.htm

Interdiciplinary Reaserch

Dr. Winn is a member of The Interdisciplinary Toxicology Program (ITP) at the University of Georgia. This program is dedicated to the high quality graduate education and excellence in research, with the goal of providing strong interdisciplinary graduate training, research and service programs in toxicology.  To find out more about this program click on the link to the Interdisciplinary Toxicology Program.
http://toxicology.uga.edu/

Selected Recent Publications

Winn, R. N., Norris, M. B., Brayer, K.J., Torres, C. and Muller, S. L. (2000).  Detection of mutations in transgenic fish carrying a bacteriophage lambda cII transgene target. Proceedings of the National Academy of Science  97(23):12655-12660. 

Hawkins, W.E., Clark, M.S., Shima, A., Walter, R.B., Winn, R.N., Westerfield, M.  (2001).  Four resource centers for fishes: specifies, stocks, and services.  Marine Biotechnology 3:S239-S248.

Nairn, R.S., Schmale, M.C., Stegman, J., Winn, R.N., Walter, R.B.  (2001). Aquaria fish models of human disease: reports and recommendations from working groups.  Marine Biotechnology  3:S249-S258.

Winn, R.N., Norris, M.B., Muller, S., Torres, C., Brayer, K. (2001). Bacteriophage lambda and plasmid pUR288 transgenic fish models for detecting in vivo mutations. Marine Biotechnology  3:S185-S195.

Winn, R. N. (2001). Transgenic fish as models in environmental toxicology. Institute for Laboratory Animal Research (ILAR) Journal  42 (4):322-328.

Winn, R.N., (2002). Production of transgenic fish. In Carl A. Pinkert (Ed.), Transgenic Animal Technology: A Laboratory Handbook. Academic Press, Elsevier Science. 261-278.

Geter, D.R., Winn, R.N., Fournie, J.W., Norris, M.B., DeAngelo, A.B., Hawkins, W.E. (2004). MX [3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone], a drinking water carcinogen, does not induce mutations in the liver of cII transgenic medaka. Journal of Toxicology and Environmental Health, part A, 67:373-383.

Winn, R.N., Norris, M.B. (2005). Analysis of mutations in lambda transgenic medaka using the cII mutation assay. Chapter 38. In: Techniques in Aquatic Toxicology, 2nd Ed. G.K. Ostrander (Ed.) pp. 705-734.

Winn, R.N., Kling, H., Norris, M.B. (2005). Antimutagenicity of green tea polyphenols in liver of transgenic medaka. Environmental and Molecular Mutagenesis 46:88-95.

Winn, R.N., Norris, M., Turner, J., Kimlin, M. (2005). Assessment of lambda transgenic medaka as a new model for UV mutagenesis. Transactions on Ecology and the Environment 85:205-213.

Winn, R.N. (2006). Mutagenesis in fish: Insights from the lambda transgenic medaka. In: Physiology of Fishes, 3rd Ed. Evans, D. and Clariborne, J. Eds. Taylor and Francis Group, CRC, Boca Raton, FL. pp. 503-524.

Winn, R.N., Norris, M., Lothenbach, D., Flynn, K., Hammermeister, D., Whitemanb, F., Sheedy, B., Johnson, R. (2006). Sub-chronic exposure to 1,1-dichloropropene induces framshift mutations in lambda transgenic medaka. Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis 595:52-59.

McElroy, A.E., Bogler, A., Weisbaum, D., Norris, M., Mendelman, L.V., Setlow, R., Winn, R. (2006). Uptake, metabolism, mutant frequencies and mutational spectra in lambda transgenic medaka embryos exposed to benzo(a)pyrene dosed sediments. Marine Environmental Research 62:S273-S277.

Tsuji, P.A., Winn, R.N., Walle, T. (2006). Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. Chemico-Biological Interactions 164:85-92.

Schmale, M.C., Nairne, R.S., Winn, R.N. (2007). Aquatic Animal Models of Human Disease. Comparative Biochemistry and Physiology, Part C 145:1-4.

Cachot, J., Law, M., Pottier, D., Peluhet, L., Norris, M., Budzinski, H., Winn, R. (2007) Characterization of toxic effects of sediment-associated organic pollutants using λ transgenic medaka. Environmental Science and Technology 41(22):7830-7836.

Burnnett, K.G. et. al. (2007) Fundulus as the premier teleost model in environmental biology: Opportunities for new insight using genomics. Comparative Biochemistry and Physiology, Part D2 257-286.

Winn, R.N., Majeske, A.J., Jagoe, C.H., Glenn, T.C., Smith, M.H., Norris, M. Transgenic λ medaka as a new model for germ cell mutagenesis. Environmental and Molecular Mutagenesis (In Press).

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